Seems That Way is a phrase said in Resident Evil: Umbrella Chronicles by Jill Valentine during one of Resident Evil 3 levels. It is said after Nemesis charges into the room with a rocket launcher. Craig and Dylan were the players at the time.
The line is said without any kind of context and comes out of the blue immediately after a cutscene and seems like a glitch. The phrase led to Craig and Dylan saying "Seems that Way" in RL in much the same kinds of out of context circumstances.